objective: barberry root extract contains various alkaloids that are considered as antioxidants. beneficial effect of aqueous extract of berberis integerrima root (aebir) was evaluated for renal function in diabetic rats induced by stz. material and methods: diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. diabetic rats were randomly grouped...

Background: Corn silk (CS) is widely used in Iranian traditional medicine and Feijoa sellowiana(FS) is a native plant widespread in the Southern parts of Iran. The aim of the present study was to assess renal protective activities of CS and FS against dosage induced injury by ecstasy (MDMA) using insitu rat renal perfusion (IRRP) system.Methods: Hydro-alcoholic extract of CS and FS (10, 20, 40 ...

background: corn silk (cs) is widely used in iranian traditional medicine and feijoa sellowiana(fs) is a native plant widespread in the southern parts of iran. the aim of the present study was to assess renal protective activities of cs and fs against dosage induced injury by ecstasy (mdma) using insitu rat renal perfusion (irrp) system.methods: hydro-alcoholic extract of cs and fs (10, 20, 40 ...

objective(s): this study aimed to develop drugs from natural sources to overcome the side effects of many of synthetic drugs. methanol extracts of both pericarp and seeds of pleiogynium solandri were used to investigate antioxidant, hepatoprotective, and renal function protective, analgesic, and anti-inflammatory effects and to determine the chemical composition of the extract responsible for b...

background and aims: methotrexate (mtx), a folic acid antagonist, is widely used as a treatment for malignancies as well as in the treatment of various inflammatory and autoimmune disorders. nephrotoxicity is an important side-effect of this drug. prevention and treatment of mtx-induced renal dysfunction are essential to prevent potentially life-threatening mtx-associated toxicities, present st...

Objective(s): This study aimed to develop drugs from natural sources to overcome the side effects of many of synthetic drugs. Methanol extracts of both pericarp and seeds of Pleiogynium solandri were used to investigate antioxidant, hepatoprotective, and renal function protective, analgesic, and anti-inflammatory effects and to determine the chemical composition of the extract responsible for b...

Introduction: Renal ischemia/reperfusion (I/R) injury due to reactive oxygen species (ROS) formation is the main cause of acute kidney damage. Nitric oxide (NO) biosynthesis and oxidative stress are closely related to the pathogenesis of renal I/R injury. This study was undertaken to determine the effects of L-arginine (L-arg) as NO donor and aerobic exercise (EX) and also the combination of L-...

conclusions the pattern of pretreatment with o2 could change this potential and highly protective strategy against cp-induced nephropathy to an ineffective or even mildly deteriorating one. therefore, o2 administration before cp injection to patients with cancer, for therapeutic purposes or as a preconditioning approach, should be performed and investigated with caution until exact effects of d...